Archives: “Therapeutic Development”

Drew Weissman, MD, PhD

https://www.coltonconsortium.org/directory/drew-weissman-md-phd/

Roberts Family Professor in Vaccine Research, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Drew Weissman is the Roberts Family Professor in Vaccine Research and Director of […]

Christoph Ellebrecht, MD

https://www.coltonconsortium.org/directory/christoph-ellebrecht-md/

Assistant Professor, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania Dr. Christoph Ellebrecht is an Assistant Professor of Dermatology at the Perelman School of Medicine, University of Pennsylvania, […]

Eric Shifrut, PhD

https://www.coltonconsortium.org/directory/eric-shifrut-phd/

Assistant Professor, Pathology, Gray Faculty of Medical and Health Sciences, Tel Aviv Sourasky Medical Center, Tel Aviv University Assistant Professor, Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life […]

Jacob Brenner, MD, PhD

https://www.coltonconsortium.org/directory/jacob-brenner-md-phd/

Assistant Professor, Department of Medicine (Pulmonary, Allergy and Critical Care), Perelman School of Medicine, University of Pennsylvania Dr. Jacob Brenner is an Assistant Professor of Medicine in the Division of […]

James Hoxie, MD

https://www.coltonconsortium.org/directory/james-hoxie-md/

Emeritus Professor, Department of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania Dr. James Hoxie is Emeritus Professor of Medicine in the Division of Hematology-Oncology and Co-Director of the […]

Jill P. Buyon, MD

https://www.coltonconsortium.org/directory/jill-p-buyon-md/

Sir Deryck and Lady Va Maughan Professor of Rheumatology, Department of Medicine, NYU Grossman School of Medicine / NYU Langone Health Director, Division of Rheumatology, NYU Grossman School of Medicine […]

Joseph Craft, MD

https://www.coltonconsortium.org/directory/joseph-craft-md/

Paul B. Beeson Professor of Medicine (Rheumatology), Department of Internal Medicine (Rheumatology, Allergy & Immunology), Yale School of Medicine, Yale University Professor of Immunobiology, Department of Immunobiology, Yale School of […]

Development of UBA1 Targeted Therapies in VEXAS Syndrome

https://www.coltonconsortium.org/projects/development-of-uba1-targeted-therapies-in-vexas-syndrome/

Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.

Spatial Dynamics of Intestinal B Cell Immunoreceptor Signaling in Health and Disease (IBD)

https://www.coltonconsortium.org/projects/spatial-dynamics-of-intestinal-b-cell-immunoreceptor-signaling-in-health-and-disease-ibd/

Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.

The Role and Mechanism of Aberrant Dendritic Cell Function in Autoimmunity

https://www.coltonconsortium.org/projects/the-role-and-mechanism-of-aberrant-dendritic-cell-function-in-autoimmunity/

Identifying a novel molecular regulator of tolerogenic dendritic cell function, this project uncovers how its loss triggers spontaneous multiorgan autoimmunity and exacerbates lupus — revealing a clinically relevant pathway in immune tolerance.