- Emeritus Professor, Department of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania
Dr. James Hoxie is Emeritus Professor of Medicine in the Division of Hematology-Oncology and Co-Director of the Penn Institute for RNA Innovation at the Perelman School of Medicine, University of Pennsylvania. He served as Founding Director of the Penn Center for AIDS Research for seventeen years, building one of the nation’s leading interdisciplinary HIV research centers.
Dr. Hoxie’s research has made foundational contributions to HIV envelope biology and to the discovery and characterization of HIV co-receptors CCR5 and CXCR4 — work that opened the pathway to entry-inhibitor therapeutics. He continues to advise on translational immunology and viral immunology research at Penn and is an active scientific contributor to Penn’s expanding RNA therapeutics enterprise.
As Co-Director of the Penn Institute for RNA Innovation, Dr. Hoxie helps shape Penn’s growing portfolio of mRNA and RNA-based therapies, with particular interest in their application to infection, immunity, and autoimmunity. He is a senior collaborator within the Institute for Immunology and Immune Health and the Penn Colton Center, where his decades of cross-institutional leadership inform strategic and scientific development.