Archives: “Archives”

ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells

CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity

Yale Study Discovers a Second Pathway for Gut Antibody Production — With Implications for Vaccine Design

A Colton-supported Yale study has uncovered a second pathway for gut IgA antibody production, revealing a built-in immune backup system with significant implications for mucosal vaccine design.

Yale Researchers Identify Two New Therapeutic Targets for Fibrotic Diseases Like Scleroderma and Lupus

Two Yale studies have identified a promising new antibody therapy and a previously unknown signaling pathway as potential treatments for fibrotic autoimmune diseases including scleroderma, lupus, and graft-versus-host disease.

NYU Langone Study Identifies Precision Approach to Dialing Down Harmful T Cell Activity in Autoimmune Disease

A Colton-supported NYU Langone study has engineered a bispecific antibody that precisely silences harmful T cell activity — showing promise across mouse models of type 1 diabetes, hepatitis, and multiple sclerosis.

Yale Study Overturns Decades of Dogma: T Cells Live in the Healthy Brain Via a Gut-Fat-Brain Axis

A Colton-supported Yale study published in Nature has shown for the first time that T cells live in the healthy brain, traveling there from the gut via a newly discovered gut-fat-brain axis.

Yale Study Finds Skin Injury Can Trigger Food Allergies Via a Skin-Gut Immune Connection

A Colton-supported Yale study published in Science Immunology shows that skin injury can trigger food allergies via a skin-gut immune connection — offering a new explanation for the link between eczema and food allergy.

New Hope for Sjögren’s Disease Patients: NYU Study Links Calcium Signaling and T Cell Dysfunction to the Condition

A Colton-supported NYU study published in Science Translational Medicine has identified impaired regulatory T cells as a key driver of Sjögren's disease — and found a promising existing drug as a potential therapy.

Yale’s Colton Center Awards $750K to Seven Autoimmune Disease Research Projects

Yale's Colton Center for Autoimmunity has awarded $750,000 to seven faculty-led projects advancing research into autoimmune and allergic diseases, with funding, mentorship, and commercialization support.