Penn Colton Center researcher Montserrat Anguera reveals how B cells maintain X chromosome inactivation, and how its breakdown drives lupus, offering new insight into female-biased autoimmune disease and treatment targets.
A Colton-supported Yale study has produced ImmunoStruct, a machine learning model that improves personalized cancer vaccine design by incorporating the 3D structure of immune-activating peptides — now licensed to a Yale spinout.
A Colton-supported Yale study has uncovered a second pathway for gut IgA antibody production, revealing a built-in immune backup system with significant implications for mucosal vaccine design.
Two Yale studies have identified a promising new antibody therapy and a previously unknown signaling pathway as potential treatments for fibrotic autoimmune diseases including scleroderma, lupus, and graft-versus-host disease.
A Colton-supported NYU Langone study has engineered a bispecific antibody that precisely silences harmful T cell activity — showing promise across mouse models of type 1 diabetes, hepatitis, and multiple sclerosis.
A Colton-supported Yale study published in Nature has shown for the first time that T cells live in the healthy brain, traveling there from the gut via a newly discovered gut-fat-brain axis.
A Colton-supported Yale study published in Science Immunology shows that skin injury can trigger food allergies via a skin-gut immune connection — offering a new explanation for the link between eczema and food allergy.
Yale researchers have found that a lupus-related antibody can penetrate "cold" tumors and activate immune responses — offering a promising new approach to treating glioblastoma and other hard-to-treat cancers.
A Colton-supported NYU study published in Science Translational Medicine has identified impaired regulatory T cells as a key driver of Sjögren's disease — and found a promising existing drug as a potential therapy.
A Colton-supported NYU study published in Science Immunology has discovered that the immune checkpoint protein PD-1 functions as a dimer — a finding that could transform drug design for both cancer and autoimmune disease.
