An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction
https://www.coltonconsortium.org/publications/an-autoimmune-transcriptional-circuit-drives-foxp3-regulatory-t-cell-dysfunction/
Yale's Colton Center for Autoimmunity has selected nine researchers for nearly $1 million in 2025 funding, backing projects that apply AI, nanoparticles, and novel biologics to autoimmune disease.
Global leaders in autoimmune research gathered for the 2025 Colton Consortium Symposium last month, sharing breakthroughs from foundational science to translational therapies and forging collaborations to improve patient lives worldwide.
The Penn Colton Center has launched two new Centers of Excellence — HIT-AI, focused on AI-driven drug repurposing, and CREATE, pioneering mRNA therapies — to accelerate next-generation autoimmune diagnostics and treatments.
A Colton-supported NYU Langone study has engineered a bispecific antibody that precisely silences harmful T cell activity — showing promise across mouse models of type 1 diabetes, hepatitis, and multiple sclerosis.
A Colton-supported Yale study published in Nature has shown for the first time that T cells live in the healthy brain, traveling there from the gut via a newly discovered gut-fat-brain axis.
Tel Aviv University's Colton Center has awarded nine interdisciplinary research grants in 2024, funding projects that explore autoimmune disease from organ-on-a-chip platforms to the role of stress and psychological factors in disease flare-ups.
Penn Medicine's Colton Center is leading a new wave of precision immunotherapy for autoimmune disease — from CAAR T cell therapy for pemphigus to immune profiling tools that could one day cure these conditions.
Tel Aviv University's Colton Center for Autoimmunity joins a four-university consortium dedicated to finding cures for over 100 autoimmune diseases through big data analytics, multidisciplinary research, and international collaboration.
Penn Medicine's new Colton Center for Autoimmunity unites the university's immunology research and patient care programs, joining NYU and Yale in a shared effort to advance autoimmune disease diagnosis and treatment.