Archives: “Archives”

David N. Assis, MD

https://www.coltonconsortium.org/directory/david-n-assis-md/

Associate Professor, Department of Internal Medicine (Digestive Diseases), Yale School of Medicine, Yale University Dr. David N. Assis is an Associate Professor of Medicine in the Section of Digestive Diseases […]

Ken Cadwell, PhD

https://www.coltonconsortium.org/directory/ken-cadwell-phd/

T. Grier Miller Professor of Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Ken Cadwell is the T. Grier Miller Professor of Medicine at the Perelman […]

Kevan C. Herold, MD

https://www.coltonconsortium.org/directory/kevan-c-herold-md/

C.N.H. Long Professor, Department of Immunobiology, Yale School of Medicine, Yale University Professor, Department of Endocrinology, Yale School of Medicine, Yale University Dr. Kevan C. Herold is the C.N.H. Long Professor […]

Manolis Roulis, PhD

https://www.coltonconsortium.org/directory/manolis-roulis-phd/

Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Manolis Roulis is Assistant Professor of Pathology and Laboratory Medicine at the Perelman School […]

Stefan Feske, MD

https://www.coltonconsortium.org/directory/stefan-feske-md/

Vice Chair for Research, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health Jeffrey Bergstein Professor of Medicine, Department of Pathology, NYU Grossman School of Medicine / NYU […]

Hajera Amatullah, PhD

https://www.coltonconsortium.org/directory/hajera-amatullah-phd/

Assistant Professor, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania Dr. Hajera Amatullah is an Assistant Professor of Systems Pharmacology and Translational Therapeutics at […]

Developing New Mode-of-Action Calcineurin Inhibitors for Acute Colitis Therapeutics

https://www.coltonconsortium.org/projects/developing-new-mode-of-action-calcineurin-inhibitors-for-acute-colitis-therapeutics/

Targeting the calcineurin-NFAT protein-protein interaction rather than enzyme active sites, this project develops a novel class of inhibitors to treat steroid-refractory ulcerative colitis with fewer side effects.

The Role of Glycosylation in Inflammatory Bowel Disease

https://www.coltonconsortium.org/projects/the-role-of-glycosylation-in-inflammatory-bowel-disease/

Investigating how foreign sugar modifications on anti-TNF biologics trigger immune responses in pediatric IBD patients, this project aims to personalize biologic therapy selection and inform safer drug design.

A Data-Driven Framework for Predicting and Managing Flares in Inflammatory Bowel Disease

https://www.coltonconsortium.org/projects/a-data-driven-framework-for-predicting-and-managing-flares-in-inflammatory-bowel-disease/

Combining machine learning with microbiome and metabolomic data from 4,000+ IBD patients, this project develops tools to predict disease flares, identify therapeutic targets, and enable personalized flare prevention.

Spatial Dynamics of Intestinal B Cell Immunoreceptor Signaling in Health and Disease (IBD)

https://www.coltonconsortium.org/projects/spatial-dynamics-of-intestinal-b-cell-immunoreceptor-signaling-in-health-and-disease-ibd/

Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.