- Vice Chair for Research, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health
- Jeffrey Bergstein Professor of Medicine, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health
- Director, Ion Channels & Transporters in Immunity (ICTI) Program, NYU Langone Health
Dr. Stefan Feske holds the Jeffrey Bergstein Professorship in Medicine and serves as Vice Chair for Research in the Department of Pathology, Director of the Ion Channels & Transporters in Immunity (ICTI) program, and Co-Director of the Translational Immunology Center (TrIC) at NYU Grossman School of Medicine. He earned his medical degree from the University of Freiburg, Germany, and completed postdoctoral training at the Max Planck Institute for Immunobiology and the Immune Disease Institute at Harvard Medical School.
Dr. Feske has made landmark contributions to the field of calcium signaling in immunity. He was central to identifying ORAI1 as the pore-forming subunit of the CRAC channel and to characterizing the first patients with ORAI1 and STIM1 mutations — work that defined a novel disease entity now known as CRAC channelopathy. His laboratory has since deepened our understanding of how CRAC channels shape lymphocyte function, influencing gene expression and cellular metabolism across a broad range of immune contexts, including infection, cancer, autoimmunity, and allergy. More broadly, the Feske lab investigates ion channels, transporters, and ionic signaling pathways that regulate immune responses in both health and disease.
This foundational work has driven the development of CRAC channel inhibitors as a new class of immunotherapeutic agents. Dr. Feske is a scientific co-founder of CalciMedica, a biotechnology company advancing CRAC channel inhibitors through clinical trials.
