- Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
Dr. Manolis Roulis is Assistant Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine. He received his diploma from the University of Athens in 2005 and his PhD from the University of Ioannina and the Biomedical Sciences Research Center Alexander Fleming in 2009, completing postdoctoral training at Fleming and serving as Associate Research Scientist at Yale University in the laboratory of Richard Flavell from 2015 to 2023.
The Roulis laboratory studies intestinal mesenchymal cells — fibroblasts and stromal populations — and their contribution to inflammatory bowel disease and colorectal cancer. His landmark Nature paper defined a distinct Cox-2–expressing fibroblast population that regulates intestinal inflammation and tumorigenesis, and his group continues to apply single-cell approaches, organoid co-culture systems, and animal models to dissect stromal-immune crosstalk in the gut.
Dr. Roulis is a recent recruit to Penn and an active member of the Penn Colton Center for Autoimmunity, the Institute for Immunology and Immune Health, and the Penn Digestive and Liver Center. His work brings novel mechanistic insight into the non-immune cellular drivers of intestinal autoimmune and inflammatory disease.