At the 2025 Yale Innovation Summit, the Colton Center for Autoimmunity hosted a showcase of Colton-funded research projects from across the Consortium, highlighting the translational potential of cutting-edge autoimmune science. The session brought together researchers from the University of Pennsylvania, New York University, and Yale University to present work spanning novel therapeutics, biologics, and diagnostics — several of which have already attracted commercial interest or launched startup companies.
Presenters included Professor Taku Kambayashi and Professor Michela Locci of the University of Pennsylvania, Dr. Jun Wang of New York University, and Dr. James Hansen of Yale University.
Watch the full Colton Center for Autoimmunity Showcase from the 2025 Yale Innovation Summit
Featured Experts
Sara Baier, MEd
Associate Director of External Relations, Colton Consortium for Autoimmunity
Colton Center for Autoimmunity, Perelman School of Medicine, University of Pennsylvania
Jennifer Gillen, MBA
Administrative Manager, Judith & Stewart Colton Center for Autoimmunity (NYU)
Department of Medicine, NYU Grossman School of Medicine / NYU Langone Health, New York University
Kenneth Hassinger
Director of Finance, Colton Consortium for Autoimmunity
Colton Center for Autoimmunity, Perelman School of Medicine, University of PennsylvaniaFeatured Projects
Utilizing RNA Replicons as Immune Modulators for Systemic Lupus Erythematosus
A self-replicating RNA platform delivers anti-inflammatory cytokines directly to the airways, offering targeted local immune suppression without systemic toxicity — a mechanistically distinct approach to treating lupus lung disease.
Developing New Mode-of-Action Calcineurin Inhibitors for Acute Colitis Therapeutics
Targeting the calcineurin-NFAT protein-protein interaction rather than enzyme active sites, this project develops a novel class of inhibitors to treat steroid-refractory ulcerative colitis with fewer side effects.
Featured Publications
Tolebrutinib in nonrelapsing secondary progressive multiple sclerosis
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