T. Grier Miller Professor of Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Ken Cadwell is the T. Grier Miller Professor of Medicine at the Perelman […]
Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Manolis Roulis is Assistant Professor of Pathology and Laboratory Medicine at the Perelman School […]
Vice Chair for Research, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health Jeffrey Bergstein Professor of Medicine, Department of Pathology, NYU Grossman School of Medicine / NYU […]
Investigating how foreign sugar modifications on anti-TNF biologics trigger immune responses in pediatric IBD patients, this project aims to personalize biologic therapy selection and inform safer drug design.
Combining machine learning with microbiome and metabolomic data from 4,000+ IBD patients, this project develops tools to predict disease flares, identify therapeutic targets, and enable personalized flare prevention.
Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.
Targeting the calcineurin-NFAT protein-protein interaction rather than enzyme active sites, this project develops a novel class of inhibitors to treat steroid-refractory ulcerative colitis with fewer side effects.
