https://www.coltonconsortium.org/directory/stefan-feske-md/
Vice Chair for Research, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health Jeffrey Bergstein Professor of Medicine, Department of Pathology, NYU Grossman School of Medicine / NYU […]
https://www.coltonconsortium.org/directory/aristotelis-tsirigos-phd/
Professor, Department of Medicine, NYU Grossman School of Medicine / NYU Langone Health Professor, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health Co-Director, Division of Precision […]
https://www.coltonconsortium.org/directory/david-b-beck-md-phd/
Associate Director, Judith & Stewart Colton Center for Autoimmunity, NYU Grossman School of Medicine / NYU Langone Health, New York University Assistant Professor, Department of Medicine, NYU Grossman School of […]
https://www.coltonconsortium.org/projects/novel-tools-to-track-and-manipulate-immune-cells-in-autoimmunity-models/
Developing a cell-labeling tool to map immune cell interactions in living tissue, this project identifies the drivers of skin-resident T cell persistence in psoriasis and potential targets for disease prevention.
https://www.coltonconsortium.org/projects/early-detection-and-diagnosis-of-autoimmune-diseases-using-foundation-ai-models/
Applying self-supervised AI to multi-modal electronic health records — integrating clinical notes, labs, and imaging — this project builds scalable diagnostic models to detect autoimmune diseases earlier and more precisely.
https://www.coltonconsortium.org/projects/development-of-uba1-targeted-therapies-in-vexas-syndrome/
Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.
https://www.coltonconsortium.org/projects/spatial-dynamics-of-intestinal-b-cell-immunoreceptor-signaling-in-health-and-disease-ibd/
Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.
https://www.coltonconsortium.org/projects/the-role-and-mechanism-of-aberrant-dendritic-cell-function-in-autoimmunity/
Identifying a novel molecular regulator of tolerogenic dendritic cell function, this project uncovers how its loss triggers spontaneous multiorgan autoimmunity and exacerbates lupus — revealing a clinically relevant pathway in immune tolerance.
https://www.coltonconsortium.org/projects/utilizing-rna-replicons-as-immune-modulators-for-systemic-lupus-erythematosus/
A self-replicating RNA platform delivers anti-inflammatory cytokines directly to the airways, offering targeted local immune suppression without systemic toxicity — a mechanistically distinct approach to treating lupus lung disease.
https://www.coltonconsortium.org/projects/wearables-and-ai-framework-for-inflammatory-arthritis-assessment-and-management/
Using wearable sensors and machine learning to analyze real-world movement and sleep data, this project aims to predict treatment response earlier and enable more personalized care for inflammatory arthritis.