Archives: “Archives”

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Stefan Feske, MD

https://www.coltonconsortium.org/directory/stefan-feske-md/

Vice Chair for Research, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health Jeffrey Bergstein Professor of Medicine, Department of Pathology, NYU Grossman School of Medicine / NYU […]

Aristotelis Tsirigos, PhD

https://www.coltonconsortium.org/directory/aristotelis-tsirigos-phd/

Professor, Department of Medicine, NYU Grossman School of Medicine / NYU Langone Health Professor, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health Co-Director, Division of Precision […]

David B. Beck, MD, PhD

https://www.coltonconsortium.org/directory/david-b-beck-md-phd/

Associate Director, Judith & Stewart Colton Center for Autoimmunity, NYU Grossman School of Medicine / NYU Langone Health, New York University Assistant Professor, Department of Medicine, NYU Grossman School of […]

Novel Tools to Track and Manipulate Immune Cells in Autoimmunity Models

https://www.coltonconsortium.org/projects/novel-tools-to-track-and-manipulate-immune-cells-in-autoimmunity-models/

Developing a cell-labeling tool to map immune cell interactions in living tissue, this project identifies the drivers of skin-resident T cell persistence in psoriasis and potential targets for disease prevention.

Early Detection and Diagnosis of Autoimmune Diseases Using Foundation AI Models

https://www.coltonconsortium.org/projects/early-detection-and-diagnosis-of-autoimmune-diseases-using-foundation-ai-models/

Applying self-supervised AI to multi-modal electronic health records — integrating clinical notes, labs, and imaging — this project builds scalable diagnostic models to detect autoimmune diseases earlier and more precisely.

Development of UBA1 Targeted Therapies in VEXAS Syndrome

https://www.coltonconsortium.org/projects/development-of-uba1-targeted-therapies-in-vexas-syndrome/

Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.

The Role and Mechanism of Aberrant Dendritic Cell Function in Autoimmunity

https://www.coltonconsortium.org/projects/the-role-and-mechanism-of-aberrant-dendritic-cell-function-in-autoimmunity/

Identifying a novel molecular regulator of tolerogenic dendritic cell function, this project uncovers how its loss triggers spontaneous multiorgan autoimmunity and exacerbates lupus — revealing a clinically relevant pathway in immune tolerance.

Utilizing RNA Replicons as Immune Modulators for Systemic Lupus Erythematosus

https://www.coltonconsortium.org/projects/utilizing-rna-replicons-as-immune-modulators-for-systemic-lupus-erythematosus/

A self-replicating RNA platform delivers anti-inflammatory cytokines directly to the airways, offering targeted local immune suppression without systemic toxicity — a mechanistically distinct approach to treating lupus lung disease.

Wearables and AI Framework for Inflammatory Arthritis Assessment and Management

https://www.coltonconsortium.org/projects/wearables-and-ai-framework-for-inflammatory-arthritis-assessment-and-management/

Using wearable sensors and machine learning to analyze real-world movement and sleep data, this project aims to predict treatment response earlier and enable more personalized care for inflammatory arthritis.