Areas of Focus:

Biological & MechanisticHuman GeneticsInnate ImmunityAutoinflammatory Diseases
  • Associate Director, Judith & Stewart Colton Center for Autoimmunity, NYU Grossman School of Medicine / NYU Langone Health, New York University
  • Assistant Professor, Department of Medicine, NYU Grossman School of Medicine, New York University

Dr. David B. Beck is an Assistant Professor in the Center for Human Genetics and Genomics and the Department of Medicine, Division of Rheumatology at NYU Grossman School of Medicine. He completed his BA at Brown University and his MD and PhD in Biochemistry through the Medical Scientist Training Program at NYU under Dr. Danny Reinberg. He subsequently completed Internal Medicine training at Columbia University as part of the Clinician Scientist Pathway and a Clinical Genetics fellowship at the National Institutes of Health, where he also trained as a postdoctoral fellow in the laboratory of Dr. Dan Kastner, helping to identify the role of somatic mutations in autoinflammatory diseases.

Dr. Beck’s research focuses on uncovering the genetic underpinnings of rheumatic diseases and translating laboratory discoveries into clinical insights. He leads a translational program dedicated to autoinflammatory diseases — including VEXAS syndrome — bridging bench research with direct patient care. His work integrating human genetics and genomics with clinical rheumatology has been recognized with awards from the National Institutes of Health, the Arthritis Research Foundation, the Burroughs Wellcome Fund Career Award for Medical Scientists, and the Henry Kunkel Society.

Projects

Featured Pilot Projects

Development of UBA1 Targeted Therapies in VEXAS Syndrome
Project | New York University

Development of UBA1 Targeted Therapies in VEXAS Syndrome

Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.