Archives: “Immune Profiling”

Molecular Determinants of Systemic Immune Reactivation in Patients with ANCA-Associated Vasculitis

Profiling deep immune changes before AAV relapse to identify predictive biomarkers and therapeutic targets for this difficult-to-manage autoimmune vasculitis.

Comprehensive Mapping of Antigenic Landscapes in Sjögren’s Disease Using Enhanced T-Scan Technology

Mapping the full antigenic landscape of Sjögren's disease using T-Scan technology to identify the drivers of autoimmune T cell responses and enable targeted therapies.

Use of AI-Enhanced Pattern Recognition and Autoantibody Discovery to Improve Anti-Nuclear Antibody Testing

Modernizing anti-nuclear antibody testing by combining AI-enhanced image analysis with multiplex autoantibody profiling to improve diagnostic precision and uncover novel autoimmune biomarkers.

Profiling Immune Responses to Improve Therapeutics

Profiling immune responses in severe asthma patients before and after biologic treatment to identify biomarkers of response and novel drug targets.

Transcriptomic profiling after B cell depletion reveals central and peripheral immune cell changes in multiple sclerosis

Sequential class switching generates antigen-specific gut IgA from IgG1 B cells

Skin damage signals mediate allergic sensitization to spatially unlinked antigen

Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa

Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup

Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes