Joseph Hollander Chair in Pediatric Rheumatology, Children’s Hospital of Philadelphia Chief, Division of Rheumatology, Children’s Hospital of Philadelphia Assistant Professor of Pediatrics, Perelman School of Medicine, University of Pennsylvania Dr. […]
Associate Professor, Department of Pediatrics (Rheumatology), Children’s Hospital of Philadelphia / University of Pennsylvania Dr. Scott Canna is Associate Professor of Pediatrics in the Division of Rheumatology at the Children’s […]
Associate Professor, Department of Immunobiology, Department of Immunobiology, Yale School of Medicine, Yale University Associate Director of Human and Translational Immunology, Department of Immunobiology, Yale School of Medicine, Yale University […]
Elizabeth Mears and House Jameson Professor, Department of Psychiatry, Yale School of Medicine, Yale University Dr. Christopher Pittenger is the Mears & Jameson Professor and Deputy Chair for Translational Research […]
Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.
Identifying a novel molecular regulator of tolerogenic dendritic cell function, this project uncovers how its loss triggers spontaneous multiorgan autoimmunity and exacerbates lupus — revealing a clinically relevant pathway in immune tolerance.
A self-replicating RNA platform delivers anti-inflammatory cytokines directly to the airways, offering targeted local immune suppression without systemic toxicity — a mechanistically distinct approach to treating lupus lung disease.
By profiling genetic and molecular drivers of pemphigus vulgaris across patient skin and blood, this project uncovers genotype-driven inflammatory loops and actionable targets for personalized therapy.
Investigating how foreign sugar modifications on anti-TNF biologics trigger immune responses in pediatric IBD patients, this project aims to personalize biologic therapy selection and inform safer drug design.
Developing a cell-labeling tool to map immune cell interactions in living tissue, this project identifies the drivers of skin-resident T cell persistence in psoriasis and potential targets for disease prevention.
