Areas of Focus:

Animal ModelsBiological & MechanisticCytokine SignalingExperimental Platforms & ModelsInnate ImmunityTranslational & ClinicalCross-Cutting & Special PopulationsPediatric Autoimmune DiseasesRare Autoimmune DiseasesSystemic DiseasesSystemic Lupus Erythematosus (SLE)
  • Joseph Hollander Chair in Pediatric Rheumatology, Children’s Hospital of Philadelphia
  • Chief, Division of Rheumatology, Children’s Hospital of Philadelphia
  • Assistant Professor of Pediatrics, Perelman School of Medicine, University of Pennsylvania

Dr. Edward Behrens is the Joseph Lee Hollander Chair in Pediatric Rheumatology and Chief of the Division of Pediatric Rheumatology at the Children’s Hospital of Philadelphia, with a faculty appointment as Professor of Pediatrics at the Perelman School of Medicine. He completed postdoctoral training at Penn in the laboratories of Stefania Gallucci and Gary Koretzky and joined the CHOP/Penn faculty in 2009, becoming division chief in 2014.

The Behrens laboratory investigates the pathogenesis and treatment of cytokine storm syndromes, including hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) — uniquely pediatric immunologic conditions that cause severe systemic inflammation and carry high mortality. He developed a novel murine model of MAS that enabled careful dissection of disease mediators, and his more recent work explores non-immune cell contributions to MAS pathology.

An internationally recognized leader in pediatric rheumatology, Dr. Behrens has received multiple awards from the American College of Rheumatology, the Histiocyte Society, and the Arthritis Foundation. He is a senior member of the Penn Colton Center for Autoimmunity and the Institute for Immunology and Immune Health, anchoring CHOP–Penn collaborative work in cytokine storm syndromes and pediatric autoimmunity.