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Edward Behrens, MD

https://www.coltonconsortium.org/directory/edward-behrens-md/

Joseph Hollander Chair in Pediatric Rheumatology, Children’s Hospital of Philadelphia Chief, Division of Rheumatology, Children’s Hospital of Philadelphia Assistant Professor of Pediatrics, Perelman School of Medicine, University of Pennsylvania Dr. […]

Scott Canna, MD

https://www.coltonconsortium.org/directory/scott-canna-md/

Associate Professor, Department of Pediatrics (Rheumatology), Children’s Hospital of Philadelphia / University of Pennsylvania Dr. Scott Canna is Associate Professor of Pediatrics in the Division of Rheumatology at the Children’s […]

Carrie Lucas, PhD

https://www.coltonconsortium.org/directory/carrie-lucas-phd/

Associate Professor, Department of Immunobiology, Department of Immunobiology, Yale School of Medicine, Yale University Associate Director of Human and Translational Immunology, Department of Immunobiology, Yale School of Medicine, Yale University […]

Development of UBA1 Targeted Therapies in VEXAS Syndrome

https://www.coltonconsortium.org/projects/development-of-uba1-targeted-therapies-in-vexas-syndrome/

Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.

The Role of Glycosylation in Inflammatory Bowel Disease

https://www.coltonconsortium.org/projects/the-role-of-glycosylation-in-inflammatory-bowel-disease/

Investigating how foreign sugar modifications on anti-TNF biologics trigger immune responses in pediatric IBD patients, this project aims to personalize biologic therapy selection and inform safer drug design.

Targets of Autoimmune Attack in Acquired Aplastic Anemia

https://www.coltonconsortium.org/projects/targets-of-autoimmune-attack-in-acquired-aplastic-anemia/

Identifying the autoantigens and T cell clonotypes driving immune attack in aplastic anemia to enable more precise diagnostics and targeted therapies.