Archives: “Archives”

Using Genetically Engineered Models to Study Pre-Autoimmune States

Using the RIP-NINJA mouse model to study how PD-1 regulation in the pancreas prevents autoimmune induction and checkpoint therapy-induced diabetes.

Generation and Validation of a New Humanized Mouse Model, A Surrogate for Human Celiac Disease

Developing and validating a humanized MISTRG6 mouse model that accurately replicates human immune responses to gluten for celiac disease research and drug development.

Noninvasive Skin Protein Assessment to Guide Targeted Treatment Selection in Inflammatory Skin Diseases

Using DIPS, a non-invasive skin sampling technique, to build cytokine-based biomarker panels that predict biologic treatment response in psoriasis and atopic dermatitis.

Targeted Biologic Therapy for Autoimmune Disease Associated with DNAseIL3 Deficiency

Developing a bioavailable DNAseIL3 biologic to degrade pathogenic autoantibodies and treat lupus and related autoimmune diseases.

Identifying Modifiers of Rhinovirus-Induced Pathological Inflammation to Combat Asthma

Identifying the signaling pathways that drive rhinovirus-induced airway inflammation to find small molecule drugs that prevent asthma attacks.

Profiling Urine Methylation in Lupus Nephritis

Identifying urine DNA methylation signatures as a non-invasive biomarker for lupus nephritis class and disease progression.

The multiple roles of gamma interferon in intraepithelial T cell-villous enterocyte interactions in active celiac disease

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab

Transcriptomic profiling after B cell depletion reveals central and peripheral immune cell changes in multiple sclerosis