Professor, Department of Radiology, Perelman School of Medicine, University of Pennsylvania Dr. Abass Alavi is a Professor of Radiology and Neurology and Director of Research Education in the Department of […]
Jonathan E. Rhoads Professor of Surgical Science II, Department of Surgery, Perelman School of Medicine, University of Pennsylvania Dr. Ali Naji is the J. William White Professor of Surgical Research […]
Melissa and Paul Anderson President’s Distinguished Professor, Department of Neurology, Perelman School of Medicine, University of Pennsylvania Dr. Amit Bar-Or is the inaugural Melissa and Paul Anderson President’s Distinguished Professor […]
Developing a cell-labeling tool to map immune cell interactions in living tissue, this project identifies the drivers of skin-resident T cell persistence in psoriasis and potential targets for disease prevention.
Applying self-supervised AI to multi-modal electronic health records — integrating clinical notes, labs, and imaging — this project builds scalable diagnostic models to detect autoimmune diseases earlier and more precisely.
Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.
Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.
Identifying a novel molecular regulator of tolerogenic dendritic cell function, this project uncovers how its loss triggers spontaneous multiorgan autoimmunity and exacerbates lupus — revealing a clinically relevant pathway in immune tolerance.
A self-replicating RNA platform delivers anti-inflammatory cytokines directly to the airways, offering targeted local immune suppression without systemic toxicity — a mechanistically distinct approach to treating lupus lung disease.
Targeting the calcineurin-NFAT protein-protein interaction rather than enzyme active sites, this project develops a novel class of inhibitors to treat steroid-refractory ulcerative colitis with fewer side effects.
