Archives: “Archives”

Spatial Dynamics of Intestinal B Cell Immunoreceptor Signaling in Health and Disease (IBD)

Using single-molecule imaging to visualize B cell receptor signaling across gut compartments, this project uncovers how intestinal B cell education breaks down in IBD, revealing new targets for therapeutic intervention.

Defining Endotypes in Hidradenitis Suppurativa to Improve Treatment

Using spatial transcriptomics to map distinct HS disease endotypes and identify targeted therapeutic strategies for this underserved inflammatory skin disease.

Penn/CHOP Immune Kidney Disease Collaboratory

Building a spatial single-cell atlas of healthy and diseased human kidneys to redefine immune-mediated kidney disease and identify precision diagnostic and therapeutic targets.

Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody

Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa

Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems

T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B

LB1037 single-cell and spatial transcriptomics reveal elevated pro-inflammatory fibroblasts and hormonal activity in hidradenitis suppurativa

Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation