Human Cohorts
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https://www.coltonconsortium.org/projects/molecular-determinants-of-systemic-immune-reactivation-in-patients-with-anca-associated-vasculitis/
Profiling deep immune changes before AAV relapse to identify predictive biomarkers and therapeutic targets for this difficult-to-manage autoimmune vasculitis.
https://www.coltonconsortium.org/projects/penn-chop-immune-kidney-disease-collaboratory/
Building a spatial single-cell atlas of healthy and diseased human kidneys to redefine immune-mediated kidney disease and identify precision diagnostic and therapeutic targets.
https://www.coltonconsortium.org/projects/high-throughput-center-for-autoimmune-therapeutic-discovery-hit-ai/
Systematically identifying and validating repurposed FDA-approved drugs for over 160 autoimmune diseases using AI, knowledge graphs, and high-throughput experimental screening.
https://www.coltonconsortium.org/publications/the-multiple-roles-of-gamma-interferon-in-intraepithelial-t-cell-villous-enterocyte-interactions-in-active-celiac-disease/
https://www.coltonconsortium.org/publications/the-subfornical-organ-is-a-nucleus-for-gut-derived-t-cells-that-regulate-behaviour/
https://www.coltonconsortium.org/publications/trajectory-of-beta-cell-function-and-insulin-clearance-in-stage-2-type-1-diabetes-natural-history-and-response-to-teplizumab/
https://www.coltonconsortium.org/publications/transcription-factor-etv3-controls-the-tolerogenic-function-of-dendritic-cells/
You might also be interested in… Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis Rheumatology Chu, D; Schwartz, N; Ampudia, J; Guthridge, J; James, […]
https://www.coltonconsortium.org/publications/transcriptomic-profiling-after-b-cell-depletion-reveals-central-and-peripheral-immune-cell-changes-in-multiple-sclerosis/
https://www.coltonconsortium.org/publications/vessel-wall-mri-in-giant-cell-arteritis-standardized-protocol-and-scoring-approach-developed-by-an-international-working-group/
https://www.coltonconsortium.org/publications/teplizumab-induces-persistent-changes-in-the-antigen-specific-repertoire-in-individuals-at-risk-for-type-1-diabetes/