Archives: “Archives”

Hajera Amatullah, PhD

https://www.coltonconsortium.org/directory/hajera-amatullah-phd/

Assistant Professor, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania Dr. Hajera Amatullah is an Assistant Professor of Systems Pharmacology and Translational Therapeutics at […]

Jorge Henao-Mejia, MD, PhD

https://www.coltonconsortium.org/directory/jorge-henao-mejia-md-phd/

Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Jorge Henao-Mejia is Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine […]

Andrew Wells, PhD

https://www.coltonconsortium.org/directory/andrew-wells-phd/

Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Andrew Wells is Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine, […]

Cornelius Y. Taabazuing, PhD

https://www.coltonconsortium.org/directory/cornelius-y-taabazuing-phd/

Presidential Assistant Professor, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania Dr. Cornelius Taabazuing is a Presidential Assistant Professor in the Department of Biochemistry and Biophysics […]

Novel Tools to Track and Manipulate Immune Cells in Autoimmunity Models

https://www.coltonconsortium.org/projects/novel-tools-to-track-and-manipulate-immune-cells-in-autoimmunity-models/

Developing a cell-labeling tool to map immune cell interactions in living tissue, this project identifies the drivers of skin-resident T cell persistence in psoriasis and potential targets for disease prevention.

Immunotherapy-Related Adverse Effects as Models for Fragile Tolerance in Humans

https://www.coltonconsortium.org/projects/immunotherapy-related-adverse-effects-as-models-for-fragile-tolerance-in-humans/

Using cancer patients experiencing immunotherapy-triggered autoimmunity as a unique human model, this project uncovers the molecular and epigenetic mechanisms by which self-reactive T cells escape immune tolerance.

Using Genetically Engineered Models to Study Pre-Autoimmune States

https://www.coltonconsortium.org/projects/using-genetically-engineered-models-to-study-pre-autoimmune-states/

Using the RIP-NINJA mouse model to study how PD-1 regulation in the pancreas prevents autoimmune induction and checkpoint therapy-induced diabetes.

Copper Transporter SLC31A1 in Th17 Cells and Multiple Sclerosis

https://www.coltonconsortium.org/projects/copper-transporter-slc31a1-in-th17-cells-and-multiple-sclerosis/

Investigating how copper transport via SLC31A1 regulates pro-inflammatory Th17 cell activity, this project uncovers a novel link between immune cell metabolism and MS, pointing toward new therapeutic targets.

Creating Insulin Producing Beta Cells That Resist Autoimmune Destruction

https://www.coltonconsortium.org/projects/creating-insulin-producing-beta-cells-that-resist-autoimmune-destruction/

Engineering TET2-deficient beta cells that resist autoimmune attack to create replacement cell therapies for type 1 diabetes.

In Vivo Target Identification and Machine Learning Validation of Autoimmune T Cell Tissue Residence

https://www.coltonconsortium.org/projects/in-vivo-target-identification-and-machine-learning-validation-of-autoimmune-t-cell-tissue-residence/

Identifying GSPT1 as an essential, targetable vulnerability of skin-resident memory T cells to enable durable remission in chronic inflammatory skin diseases without systemic immunosuppression.