Archives: “Archives”

Jordan E. Axelrad, MD, MPH

https://www.coltonconsortium.org/directory/jordan-e-axelrad-md-mph/

Dr. Jordan E. Axelrad, is Co-Director of the Inflammatory Bowel Disease Center at NYU Langone Health, and an Associate Professor of Medicine in the Division of Gastroenterology, Department of Medicine, […]

David Fajgenbaum, MD, MBA, MSc, FCPP

https://www.coltonconsortium.org/directory/david-fajgenbaum-md-mba-msc-fcpp/

Associate Professor, Department of Medicine (Translational Medicine and Human Genetics), Perelman School of Medicine, University of Pennsylvania Dr. David Fajgenbaum is an Associate Professor of Medicine in the Division of […]

Joseph Romano, PhD

https://www.coltonconsortium.org/directory/joseph-romano-phd/

Assistant Professor, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania Dr. Joseph Romano is an Assistant Professor of Informatics and Biostatistics in the Department of […]

Sara Cherry, PhD

https://www.coltonconsortium.org/directory/sara-cherry-phd/

John W. Eckman Professor of Medical Science, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania Dr. Cherry is the John W. Eckman Professor of Medical […]

Troy Messick, PhD

https://www.coltonconsortium.org/directory/troy-messick-phd/

Research Associate Professor, Center for Advanced Therapeutics, The Wistar Institute Dr. Troy Messick is Research Associate Professor in the Genome Regulation and Cell Signaling Program of the Ellen and Ronald […]

David N. Assis, MD

https://www.coltonconsortium.org/directory/david-n-assis-md/

Associate Professor, Department of Internal Medicine (Digestive Diseases), Yale School of Medicine, Yale University Dr. David N. Assis is an Associate Professor of Medicine in the Section of Digestive Diseases […]

Development of UBA1 Targeted Therapies in VEXAS Syndrome

https://www.coltonconsortium.org/projects/development-of-uba1-targeted-therapies-in-vexas-syndrome/

Building a fluorescence-based cellular screening platform to identify small molecules targeting mutant UBA1, this project addresses an acute unmet need in VEXAS syndrome and lays groundwork for broader rheumatic disease therapies.

Utilizing RNA Replicons as Immune Modulators for Systemic Lupus Erythematosus

https://www.coltonconsortium.org/projects/utilizing-rna-replicons-as-immune-modulators-for-systemic-lupus-erythematosus/

A self-replicating RNA platform delivers anti-inflammatory cytokines directly to the airways, offering targeted local immune suppression without systemic toxicity — a mechanistically distinct approach to treating lupus lung disease.

Inhibiting NETosis with Nuclear-Penetrating Antibodies

https://www.coltonconsortium.org/projects/inhibiting-netosis-with-nuclear-penetrating-antibodies/

Repurposing nuclear-penetrating autoantibodies from lupus and scleroderma patients as potent, safe inhibitors of pathogenic NETosis.

Defining Endotypes in Hidradenitis Suppurativa to Improve Treatment

https://www.coltonconsortium.org/projects/defining-endotypes-in-hidradenitis-suppurativa-to-improve-treatment/

Using spatial transcriptomics to map distinct HS disease endotypes and identify targeted therapeutic strategies for this underserved inflammatory skin disease.