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https://www.coltonconsortium.org/projects/using-genetically-engineered-models-to-study-pre-autoimmune-states/
Using the RIP-NINJA mouse model to study how PD-1 regulation in the pancreas prevents autoimmune induction and checkpoint therapy-induced diabetes.
https://www.coltonconsortium.org/projects/a-cho-cell-based-surface-display-platform-for-comprehensive-serological-profiling/
Building a CHO cell surface display library of all human proteins to enable comprehensive, high-throughput autoantibody profiling across autoimmune diseases and vaccine responses.
https://www.coltonconsortium.org/projects/comprehensive-mapping-of-antigenic-landscapes-in-sjogrens-disease-using-enhanced-t-scan-technology/
Mapping the full antigenic landscape of Sjögren's disease using T-Scan technology to identify the drivers of autoimmune T cell responses and enable targeted therapies.
https://www.coltonconsortium.org/projects/autoantibodies-in-long-covid/
Investigating the autoimmune and immune dysregulation mechanisms underlying Long COVID to improve diagnosis, treatment, and biological understanding of persistent symptoms.
https://www.coltonconsortium.org/projects/targets-of-autoimmune-attack-in-acquired-aplastic-anemia/
Identifying the autoantigens and T cell clonotypes driving immune attack in aplastic anemia to enable more precise diagnostics and targeted therapies.
https://www.coltonconsortium.org/publications/teplizumab-induces-persistent-changes-in-the-antigen-specific-repertoire-in-individuals-at-risk-for-type-1-diabetes/
https://www.coltonconsortium.org/publications/organ-injury-in-systemic-autoimmunity-is-mediated-by-stem-like-cd8-t-cells-arising-from-tissue-draining-lymph-nodes/
https://www.coltonconsortium.org/publications/origins-of-t-cell-mediated-autoimmunity-in-acquired-aplastic-anaemia/
https://www.coltonconsortium.org/publications/elucidating-the-role-of-autoreactive-t-cells-and-b-cells-in-autoimmune-hepatitis/
https://www.coltonconsortium.org/publications/environmentally-driven-immune-imprinting-protects-against-allergy/