Archives: “Archives”

Defining Endotypes in Hidradenitis Suppurativa to Improve Treatment

Using spatial transcriptomics to map distinct HS disease endotypes and identify targeted therapeutic strategies for this underserved inflammatory skin disease.

In Vivo Target Identification and Machine Learning Validation of Autoimmune T Cell Tissue Residence

Identifying GSPT1 as an essential, targetable vulnerability of skin-resident memory T cells to enable durable remission in chronic inflammatory skin diseases without systemic immunosuppression.

Center of Excellence for Cell Therapy in Autoimmunity (CECTA)

Advancing engineered CAR and CAAR T cell therapies across multiple autoimmune diseases through clinical trials, preclinical development, and industry partnerships.

Understanding the spectrum from preclinical psoriatic arthritis to early diagnosis of the disease

Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody

Skin damage signals mediate allergic sensitization to spatially unlinked antigen

Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa

Skin manifestations of VEXAS syndrome and associated genotypes

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems

LB1037 single-cell and spatial transcriptomics reveal elevated pro-inflammatory fibroblasts and hormonal activity in hidradenitis suppurativa