- Associate Professor, Department of Pathology, NYU Grossman School of Medicine / NYU Langone Health
Dr. Sergei Koralov is a tenured Associate Professor of Pathology at NYU Grossman School of Medicine. He trained with Klaus Rajewsky — a pioneer of conditional gene targeting and B cell biology — at Harvard Medical School, and has led an independent laboratory at NYU since 2010. His group investigates how adaptive immunity is shaped at barrier surfaces, including the skin, gut, and airway, and how dysregulated lymphocyte responses and microbial signals contribute to autoimmunity, chronic inflammation, and cancer.
A central focus of the lab is the breakdown of B and T cell tolerance in autoimmune disease. Ongoing work spans several interconnected areas: the role of plasma cells and IgA in gut homeostasis; miRNA-dependent control of B cell tolerance and IgE class switching in atopic disease; the persistence of autoreactive B cell clones in primary immunodeficiency; and the cellular and molecular basis of psoriatic arthritis.
The lab also maintains an active cancer immunology program, with particular interest in how microbial triggers and aberrant cytokine signaling drive cutaneous T cell lymphoma, and in the mechanisms by which lung tumors evade immune surveillance. To support these research directions, the Koralov lab develops innovative immunological tools — including transgenic mouse platforms for rapid single-chain antibody generation, lineage tracing reporters for plasma cells, and multimodal single-cell approaches integrating transcriptomic, proteomic, clonotypic, and CRISPR perturbation readouts. Several of these technologies have advanced into industry partnerships and clinical translation.