Areas of Focus:

AutoantibodiesAutoantigensBiological & MechanisticExperimental Platforms & ModelsFunctional Genomics & CRISPRImmune ProfilingCross-Cutting & Special PopulationsRare Autoimmune DiseasesSjögren’s DiseaseSystemic Diseases
  • Assistant Professor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania

Dr. Mohammad Haj Dezfulian is Assistant Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine. He received his BSc from Tehran University and Shahid Chamran University in 2006 and his PhD in molecular biology and genetics from the University of Windsor in 2014, completing postdoctoral training at Harvard Medical School in the laboratory of Stephen Elledge.

The Haj Dezfulian laboratory develops next-generation high-throughput technologies for systematic discovery of autoantigens and characterization of antigen-specific T cell responses. He is a co-developer of PhIP-Seq and TScan-II platforms — phage display and synthetic genetic circuit technologies that enable proteome-scale identification of autoantibody and T cell receptor specificities — work published in Cell and Nature Biotechnology and broadly adopted in the field.

Dr. Haj Dezfulian is a recent recruit to Penn and a member of the Penn Colton Center for Autoimmunity, the Institute for Immunology and Immune Health, and the Abramson Cancer Center. His engineering-driven approach to immune specificity offers powerful new tools for characterizing the antigenic basis of autoimmune disease and informing the design of antigen-specific immunotherapies.

Projects

Featured Pilot Projects

Comprehensive Mapping of Antigenic Landscapes in Sjögren's Disease Using Enhanced T-Scan Technology
Project | University of Pennsylvania

Comprehensive Mapping of Antigenic Landscapes in Sjögren's Disease Using Enhanced T-Scan Technology

Mapping the full antigenic landscape of Sjögren's disease using T-Scan technology to identify the drivers of autoimmune T cell responses and enable targeted therapies.