Areas of Focus:

Adaptive ImmunityB Cell BiologyBiological & MechanisticClinical TrialsExperimental Platforms & ModelsImmune ProfilingImmune ToleranceIn Vitro ModelsTherapeutic DevelopmentTranslational & ClinicalAllergic & Atopic DiseasesAlopecia AreataDermatologic DiseasesPemphigus & PemphigoidPsoriasisVitiligo
  • Associate Professor, Department of Dermatology, Yale School of Medicine, Yale University
  • Associate Professor, Department of Pathology, Yale School of Medicine, Yale University
  • Director Yale Immunobullous Clinic, Department of Dermatology, Yale School of Medicine, Yale University
  • Director Dermatology Medical Student Education, Department of Dermatology, Yale School of Medicine, Yale University

Dr. Mary Tomayko is an Associate Professor of Dermatology and Pathology at Yale School of Medicine, where she directs the Yale Immunobullous Clinic and serves as Director of Dermatology Medical Student Education. She is a physician-scientist specializing in the diagnosis and treatment of autoimmune blistering diseases and other immune-mediated skin conditions, and serves as an attending physician at Yale Medicine Dermatology, Yale Health, and Yale-New Haven Hospital.

In her clinical practice, Dr. Tomayko evaluates individuals with complex cutaneous autoimmune and inflammatory disorders — including pemphigus, pemphigoid, epidermolysis bullosa acquisita, atopic dermatitis, vitiligo, alopecia areata, and psoriasis — employing a broad range of systemic immunomodulators, targeted biologic agents, and phototherapy.

Dr. Tomayko’s NIH-funded research laboratory pursues two intertwined missions. The first is to uncover the mechanisms of immune dysregulation in bullous pemphigoid in order to develop effective and targeted treatments. The second is to understand how long-lasting immunity to infection and immunization is established and maintained. Her seminal work has revealed unexpected diversity in the phenotype and function of cells that maintain B lymphocyte immunity and identified novel molecular pathways essential for durable immunity — findings that suggest new approaches to therapeutically enhance or suppress immune responses.

Dr. Tomayko mentors undergraduate, graduate, and medical students, and trains resident physicians and fellows, reflecting her deep commitment to education at all levels of training.