Areas of Focus:

Biological & MechanisticExperimental Platforms & ModelsIn Vitro ModelsInnate ImmunityTherapeutic DevelopmentTranslational & ClinicalOtherSystemic DiseasesSystemic Lupus Erythematosus (SLE)
  • Professor, Department of Pathology, Yale School of Medicine, Yale University

Dr. Demetrios Braddock is a Professor of Pathology at Yale School of Medicine. Born in Tennessee and educated at the University of Chicago, he completed his training at the NIH in Anatomic Pathology and Biophysical Chemistry before joining Yale in 2004, where he practices hematopathology and directs a laboratory studying pathogenic mechanisms of severe and poorly addressed human diseases.

Dr. Braddock’s laboratory focuses on rare diseases of children and on the design and engineering of novel biologics to modulate disease outcomes. A central achievement of his laboratory has been the design and validation of an enzyme biologic for Generalized Arterial Calcification of Infancy (GACI), a lethal infantile calcification disorder. This therapy has been translated into clinical trials in infants, children, and adults with GACI, ARHR2, PXE, and CKD-MBD. His laboratory is also developing targeted biologic therapies for autoimmune disease associated with DNase IL3 deficiency.

Projects

Featured Pilot Projects

Targeted Biologic Therapy for Autoimmune Disease Associated with DNAseIL3 Deficiency
Project | Yale University

Targeted Biologic Therapy for Autoimmune Disease Associated with DNAseIL3 Deficiency

Developing a bioavailable DNAseIL3 biologic to degrade pathogenic autoantibodies and treat lupus and related autoimmune diseases.