Areas of Focus:

BioinformaticsBiological & MechanisticBiomarker DiscoveryData-Driven & QuantitativeDisease SubtypingExperimental Platforms & ModelsHuman CohortsHuman GeneticsTranslational & ClinicalCross-Cutting & Special PopulationsRare Autoimmune Diseases
  • Assistant Professor, Department of Medicine (Hematology-Oncology), Perelman School of Medicine, University of Pennsylvania

Dr. Daria Babushok is an Assistant Professor of Medicine in the Division of Hematology-Oncology at the Perelman School of Medicine, University of Pennsylvania, with a clinical focus on bone marrow failure syndromes. She received her MD and PhD from the University of Pennsylvania, completed internal medicine residency at Massachusetts General Hospital, and returned to Penn for fellowship training in hematology-oncology under Monica Bessler.

Dr. Babushok’s laboratory studies the genetic and immunologic basis of acquired aplastic anemia and related immune-mediated bone marrow failure syndromes. Her group has made important contributions to defining patterns of clonal hematopoiesis and somatic HLA mutations that arise as the bone marrow attempts to escape autoimmune destruction, providing both mechanistic insight and candidate biomarkers for disease stratification and treatment response.

Through the Penn Bone Marrow Failure Program and collaborations across the Penn Colton Center and the Institute for Immunology and Immune Health, Dr. Babushok bridges human genetics, immune profiling, and clinical hematology. Her work positions Penn at the forefront of understanding rare hematologic autoimmune syndromes and provides a translational template for precision stratification of immune-mediated marrow failure.

Projects

Featured Pilot Projects

Targets of Autoimmune Attack in Acquired Aplastic Anemia
Project | University of Pennsylvania

Targets of Autoimmune Attack in Acquired Aplastic Anemia

Identifying the autoantigens and T cell clonotypes driving immune attack in aplastic anemia to enable more precise diagnostics and targeted therapies.