- Sterling Professor, Department of Molecular, Cellular, and Developmental Biology; Yale School of Medicine, Yale University
- Professor, Department of Chemistry; Faculty of Arts & Sciences (FAS), Yale University
Dr. Anna Marie Pyle is a Sterling Professor in the Departments of Molecular, Cellular and Developmental Biology and Chemistry at Yale University, and has been a Howard Hughes Medical Institute Investigator since 1997. She received her undergraduate degree in Chemistry from Princeton University and her PhD in Chemistry from Columbia University, where she worked with Professor Jacqueline Barton. She completed postdoctoral training with Thomas Cech at the University of Colorado before forming her own research group at Columbia University Medical Center in 1992. She moved to Yale in 2002.
Dr. Pyle’s laboratory uses structural biology, enzymology, and cell biology to investigate the structural complexity of large RNA molecules and the proteins that recognize them. She solved the first structures of pre-mRNA splicing machines, led efforts to characterize RNA structures in noncoding RNAs and viral genomes, and pioneered the study of RNA helicase enzymes and antiviral innate immune receptors in mammalian cells. She is also actively involved in the development of RNA as a therapeutic target, serving on the scientific advisory board of Arrakis Therapeutics.
Dr. Pyle is President of the RNA Society, Vice-Chair of the Science and Technology Steering Committee at Brookhaven National Laboratories, and a board member of the Telluride Science Research Center. She is the author of more than 190 publications and has mentored over 40 graduate students and postdoctoral fellows.