Areas of Focus:

Animal ModelsBiological & MechanisticCytokine SignalingEnvironmental ExposuresExperimental Platforms & ModelsGene–Environment InteractionsHuman CohortsInnate ImmunityMicrobiome–Immune InteractionsNeuro-Immune InteractionsPopulation & Patient-CenteredAllergic & Atopic DiseasesSystemic DiseasesSystemic Lupus Erythematosus (SLE)
  • Associate Professor, Department of Internal Medicine (Rheumatology), Yale School of Medicine, Yale University
  • Associate Professor, Department of Immunobiology, Yale School of Medicine, Yale University

Dr. Andrew Wang is an Associate Professor of Internal Medicine (Rheumatology) and Immunobiology at Yale School of Medicine. He received his AB from Harvard University and his MD and PhD from the University of Texas Southwestern in 2011, with additional training at the University of Paris. During his MD/PhD training in the laboratories of Drs. Edward Wakeland and Chandra Mohan, he identified a key role for the CXCR4/SDF-1 axis in end-organ targeting in SLE, an important insight into disease pathogenesis. He completed his internal medicine residency at Yale and joined the ABIM Short Track Pathway into rheumatology fellowship.

Dr. Wang conducted his postdoctoral training in the laboratory of Dr. Ruslan Medzhitov, where he discovered that different inflammatory states are coordinated with distinct metabolic programs — a foundational insight into the pathogenesis of inflammatory diseases. He joined the Yale faculty in 2017.

Dr. Wang’s laboratory investigates how the environment interacts with the host to affect disease trajectories, employing techniques spanning physiology, metabolism, inflammation, neurobiology, and immunology alongside patient samples. Current research directions include identifying environmental determinants of inflammatory diseases, understanding inflammatory and placebo/nocebo physiology, dissecting the moonlighting functions of the immune system, and exploring energy allocation in host defense. Clinically, he cares for patients with rheumatologic diseases and complex inflammatory conditions, often without a clear diagnosis.

Projects

Featured Pilot Projects

Understanding the Therapeutic Potential of a Novel IgE Receptor
Project | Yale University

Understanding the Therapeutic Potential of a Novel IgE Receptor

Characterizing a newly discovered IgE receptor to develop it into a drug that clears circulating IgE and treats allergic diseases.